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SINGLE-CELL RNA SEQUENCING REVEALS THE MECHANISM OF SONODYNAMIC THERAPY COMBINED WITH A RAS INHIBITOR IN THE SETTING OF HEPATOCELLULAR CARCINOMA

Ras activation is a frequent event in hepatocellular carcinoma. Combining a RAS inhibitor with traditional clinical therapeutics might...

NEW DISCOVERY SHOWS HUMAN CELLS CAN WRITE RNA SEQUENCES INTO DNA

In a discovery that challenges long-held dogma in biology, researchers show that mammalian cells can convert RNA sequences back into...

 
 
 

BP4RNASEQ: A BABYSITTER PACKAGE FOR RETROSPECTIVE AND NEWLY GENERATED RNA-SEQ DATA ANALYSES USING BOTH ALIGNMENT-BASED AND ALIGNMENT-FREE QUANTIFICATION METHOD

AbstractSummaryProcessing raw reads of RNA-sequencing data, no matter public or newly sequenced data, involves a lot of specialized...

LNCRNA KCNQ1OT1 IS A KEY FACTOR IN THE REVERSAL EFFECT OF CURCUMIN ON CISPLATIN RESISTANCE IN THE COLORECTAL CANCER CELLS

Abstract The development of cisplatin resistance is a common cause of cancer recurrence in colorectal cancer. Though many studies have...

 
 
 

BUTTERFLY: ADDRESSING THE POOLED AMPLIFICATION PARADOX WITH UNIQUE MOLECULAR IDENTIFIERS IN SINGLE-CELL RNA-SEQ

The incorporation of unique molecular identifiers in single-cell RNA-seq assays makes possible the identification of duplicated molecules,...

NOT JUST A PHASE FOR RNAS

A phenomenon in which an RNA named NORAD drives a protein named Pumilio to form liquid droplets in cells, much like oil in water, appears...

 
 
 

RIBOZYME‐PROCESSED GUIDE RNA ENHANCES VIRUS‐MEDIATED PLANT GENOME EDITING

Abstract In virus-induced gene-editing system, subgenomic promoters have been used to express guide RNAs. However, the transcription...

RESEARCHERS IMPROVE EFFICIENCY AND ACCESSIBILITY OF CRISPR

One of the most powerful tools available to biologists these days is CRISPR-Cas9, a combination of specialized RNA and protein that...

 
 
 

SCIENTISTS USE PUBLIC DATABASES TO LEAP OVER SCOURGE OF PUBLICATION BIAS

Scientists have leapt over the emerging problem of publication bias within genetic research by performing a meta-analysis of publicly...

ANALYSIS OF SINGLE-CELL RNA SEQUENCING DATA BASED ON AUTOENCODERS

Single-cell RNA sequencing experiments are gaining ground to study the molecular processes that drive normal development as well as...

 
 
 

DOUBLE MATRIX COMPLETION FOR CIRCRNA-DISEASE ASSOCIATION PREDICTION

Circular RNAs are a class of single-stranded RNA molecules with a closed-loop structure. A growing body of research has shown that...

RESOLVING HUMAN LACTATION HETEROGENEITY USING SINGLE MILK-DERIVED CELLS, A RESOURCE AT THE READY

Abstract Single cell RNA sequencing of human milk-derived cells makes highly detailed analyses of the biology of human lactation possible....

 
 
 

CIRCULAR RNA EXPRESSION PROFILE IN TRANSGENIC DIABETIC MOUSE KIDNEYS

Abstract Background Diabetic nephropathy is one of the most important complications in patients with diabetes. The etiology and pathogenesis...

DOWN-REGULATION OF SNHG16 ALLEVIATES THE ACUTE LUNG INJURY IN SEPSIS RATS THROUGH MIR-128-3P/HMGB3 AXIS

Abstract Background Long noncoding RNAs contribute to various inflammatory diseases, including sepsis. We explore the role of small...

 
 
 

SILENCING LNCRNA GAS5 ALLEVIATES APOPTOSIS AND FIBROSIS IN DIABETIC CARDIOMYOPATHY BY TARGETING MIR-26A/B-5P

Abstract Background LncRNA GAS5 is associated with high glucose-induced cardiomyocyte injury, but its role in diabetic cardiomyopathy...

EXPRESSION GRADIENT OF METALLOPROTEINASES AND THEIR INHIBITORS FROM PROXIMAL TO DISTAL SEGMENTS OF ABDOMINAL AORTIC ANEURYSM

Abstract Abdominal aortic aneurysm refers to abnormal, asymmetric distension of the infrarenal aortic wall due to pathological remodelling...

 
 
 

BMSC-DERIVED EXTRACELLULAR VESICLES INTERVENED THE PATHOGENIC CHANGES OF SCLERODERMA IN MICE THROUGH MIRNAS

Abstract Background Systemic sclerosis is a disease that features severe fibrosis of the skin and lacks effective therapy. Bone marrow...

CIRCELK4 CONTRIBUTES TO LUPUS NEPHRITIS BY ACTING AS A MIR-27B-3P SPONGE TO REGULATE STING/IRF3/IFN-I SIGNALING

Abstract Systemic lupus erythematosus is a prototypic autoimmune disease and a common complication of SLE is lupus nephritis during...

 
 
 

INHIBITION OF DIPEPTIDYL-PEPTIDASE 4 INDUCES UPREGULATION OF THE LATE CORNIFIED ENVELOPE CLUSTER IN KERATINOCYTES

Abstract Dipeptidyl-peptidase 4 is a multifunctional type II transmembrane glycoprotein that is expressed on various cell surfaces....

LONG NON-CODING RNA EXPLORATION FOR MESENCHYMAL STEM CELL CHARACTERISATION

Abstract Background The development of RNA sequencing and the corresponding emergence of public datasets have created new avenues of...