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INSIGHTS INTO THE PATHOGENICITY OF MISSENSE VARIANTS IN THE FORKHEAD DOMAIN OF FOX PROTEINS UNDERLYING MENDELIAN DISORDERS

Abstract Forkhead box proteins are members of a conserved family of transcription factors. Pathogenic variants in FOX genes have been...

NEW DISCOVERY SHOWS HUMAN CELLS CAN WRITE RNA SEQUENCES INTO DNA

In a discovery that challenges long-held dogma in biology, researchers show that mammalian cells can convert RNA sequences back into...

 
 
 

RESEARCHERS' ALGORITHM TO MAKE CRISPR GENE EDITING MORE PRECISE

Researchers have developed a new method which makes CRISPR gene editing more precise than conventional methods. The method selects...

TRANSCRIPTION SHAPES DNA REPLICATION INITIATION TO PRESERVE GENOME INTEGRITY

Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question...

 
 
 

REVIEW OF DNA MIXTURE INTERPRETATION METHODS HELPS ASSESS RELIABILITY

The National Institute of Standards and Technology has published "DNA Mixture Interpretation: A Scientific Foundation Review." This...

A TECHNIQUE FOR LABELING AND RETRIEVING DNA DATA FILES FROM A LARGE POOL COULD HELP MAKE DNA DATA STORAGE FEASIBLE

On Earth right now, there are about 10 trillion gigabytes of digital data, and every day, humans produce emails, photos, tweets, and...

 
 
 

A LIST OF BUGATTI SUPER SPORT MODELS FROM 1931 TO 2021 - THE SPEED DNA

These are some of the Bugatti models that shaped the world of hypercars, aptly wearing the Super Sport moniker. The first Bugatti Super...

NUCLEOSOME BREATHING FROM ATOMISTIC TIME SNAPSHOTS

Computer simulations visualize in atomic detail how DNA opens while wrapped around proteins.

 
 
 

RAPAMYCIN CHANGES THE WAY OUR DNA IS STORED

Our genetic material is stored in our cells in a specific way to make the meter-long DNA molecule fit into the tiny cell nucleus of...

10,000-YEAR-OLD DNA PENS THE FIRST TALES OF THE EARLIEST DOMESTICATED GOATS

New research has revealed the genetic makeup of the earliest goat herds. The findings, assimilated from DNA taken from the remains...

 
 
 

STUDY REVEALS STRUCTURAL CHANGES OF A KEY PROTEIN INVOLVED IN DNA REPAIR

Researchers of the University of Oulu, Finland, have for the first time uncovered the molecular structure of a key protein, PARP2,...

GENE SET ENRICHMENT ANALYSIS FOR GENOME-WIDE DNA METHYLATION DATA

DNA methylation is one of the most commonly studied epigenetic marks, due to its role in disease and development. Illumina methylation...

 
 
 

GUT MICROBIOME, BODY WEIGHT, AND MAMMOGRAPHIC BREAST DENSITY IN HEALTHY POSTMENOPAUSAL WOMEN

Abstract Purpose We examined gut microbiome profiles in relation to mammographic breast density and body mass index in healthy postmenopausal...

Modular Components in Industrial Architecture

MODULAR COMPONENTS IN INDUSTRIAL ARCHITECTURE

Rice Wine Factory / DnA. Industrial architecture usually requires fast installation, low-maintenance components, and flexible spaces...

 
 
 

COMPARISON OF TWO TARGETED ULTRA-DEEP SEQUENCING TECHNOLOGIES FOR ANALYSIS OF PLASMA CIRCULATING TUMOUR DNA IN ENDOCRINE-THERAPY-RESISTANT BREAST CANCER PATIENTS

Abstract Purpose There is growing interest in the application of circulating tumour DNA as a sensitive tool for monitoring tumour evolution...

META-ANALYSIS OF EPIGENOME-WIDE ASSOCIATION STUDIES OF CAROTID INTIMA-MEDIA THICKNESS

Abstract Common carotid intima-media thickness is an index of subclinical atherosclerosis that is associated with ischemic stroke and...

 
 
 

2-KUPL: MAPPING-FREE VARIANT DETECTION FROM DNA-SEQ DATA OF MATCHED SAMPLES

Abstract Background The detection of genome variants, including point mutations, indels and structural variants, is a fundamental and...

MITOCHONDRIAL DISEASE PATIENTS WITH NOVEL ND4 12058A >  C AND ND1 M.3911A >  G VARIATIONS: IMPLICATIONS FOR A ROLE IN THE PHENOTYPE FOLLOWING A BIOINFORMATIC INVESTIGATION

Abstract Mitochondrial diseases include a wide group of clinically heterogeneous disorders caused by a dysfunction of the mitochondrial...

 
 
 

MORPHOLOGY AND MOLECULAR PHYLOGENY OF TWO MARINE FOLLICULINID CILIATES FOUND IN CHINA

Abstract Ciliates of the heterotrich family Folliculinidae are characterized by their transparent lorica, conspicuous peristomial lobes...

NEW HAPLOTYPES OF APIS CERANA IN INDONESIA: IDENTIFICATION FROM MITOCHONDRIAL AND MAJOR ROYAL JELLY PROTEIN 2 GENES

Abstract Apis cerana is widely adapted to vast areas that stretch from Russia to Sundaland through Palawan in the Philippines. By using...