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THE TIGHTEST NON-AMINOGLYCOSIDE LIGAND FOR THE BACTERIAL RIBOSOMAL RNA A-SITE

A research group has made a significant discovery with positive implications for the development of bacteria-fighting drugs. The aminoacyl-tRNA...

 
 
 
Alnylam Won't Seek Quick FDA Nod For Second RNAi Drug

ALNYLAM WON'T SEEK QUICK FDA NOD FOR SECOND RNAI DRUG

A few weeks ago, Alnylam Pharmaceuticals indicated it might seek a speedy FDA approval for what could be the second-ever RNA interference...

Sequel System 6.0 Release Offers a New Paradigm in DNA Sequencing: Highly Accurate Single-Molecule Long Reads

SEQUEL SYSTEM 6.0 RELEASE OFFERS A NEW PARADIGM IN DNA SEQUENCING: HIGHLY ACCURATE SINGLE-MOLECULE LONG READS

Today we're pleased to announce the release of Sequel System 6.0 , including new software, consumable reagents and a new SMRT Cell. Combined,...

 
 
 
Bio Roundup: Nobel Prizes, Duchenne Steps, Guardant's IPO & More

BIO ROUNDUP: NOBEL PRIZES, DUCHENNE STEPS, GUARDANT'S IPO & MORE

Cancer immunotherapy is all the rage these days. The idea of harnessing the immune system to treat cancer has sparked billions of dollars...

OPTIMIZING PCR PRIMERS TARGETING THE BACTERIAL 16S RIBOSOMAL RNA GENE

Targeted amplicon sequencing of the 16S ribosomal RNA gene is one of the key tools for studying microbial diversity. The accuracy of...

 
 
 
Iso-Seq SMRT Grant Winner to Study Alternative Splicing in Neurons

ISO-SEQ SMRT GRANT WINNER TO STUDY ALTERNATIVE SPLICING IN NEURONS

Xiaochang Zhang, an assistant professor at the University of Chicago, is poised to get a powerful new data set to help his team understand...

DECODING THE STRUCTURE OF AN RNA-BASED CRISPR SYSTEM

Scientists report the detailed molecular structure of CRISPR-Cas13d, a promising enzyme for emerging RNA-editing technology. They were...

 
 
 

MAPPING VAST UNKNOWN TERRITORY OF LONG NON-CODING RNA

Scientists have developed a powerful method for exploring the properties of mysterious molecules called long non-coding RNAs , some...

Lasker Awards Recognize Propofol Discovery, Women in Science Advocate & Others

LASKER AWARDS RECOGNIZE PROPOFOL DISCOVERY, WOMEN IN SCIENCE ADVOCATE & OTHERS

The winners of the U.S.'s most prestigious awards in biomedical sciences were announced today, for work in developing propofol, the...

 
 
 

NEW TECHNIQUE REVEALS HOW ZIKA VIRUS INTERACTS INSIDE OUR CELLS

Scientists have developed a new technique that can determine how viruses interact with a host's own RNA. As well as providing insight...

New Look at Breast Cancer Cell Line Sheds Light on Structural Complexity

NEW LOOK AT BREAST CANCER CELL LINE SHEDS LIGHT ON STRUCTURAL COMPLEXITY

In an exciting paper that made the cover of Genome Research , scientists from Cold Spring Harbor Laboratory and collaborating institutions...

 
 
 

EPIGENOMIC AND TRANSCRIPTOMIC CHARACTERIZATION OF SECONDARY BREAST CANCERS

Abstract Background Molecular alterations impact tumor prognosis and response to treatment. This study was designed to identify transcriptomic...

A REGULATORY CIRCUITRY BETWEEN GRIA2, MIR-409, AND MIR-495 IS AFFECTED BY ALS FUS MUTATION IN ESC-DERIVED MOTOR NEURONS

Abstract Mutations in fused in sarcoma cause amyotrophic lateral sclerosis. FUS is a multifunctional protein involved in the biogenesis...

 
 
 
HIV RNA Expression Inhibitors as a Therapy to Restore Immune Function in HIV-Infected Persons

HIV RNA EXPRESSION INHIBITORS AS A THERAPY TO RESTORE IMMUNE FUNCTION IN HIV-INFECTED PERSONS

Use of HIV RNA expression inhibitors as additive therapy might reduce atypical inflammation and restore immune function in HIV-infected...

 
 
 
Bio Roundup: Big Approvals, ICER Influence, Drug-Price Pushback & More

BIO ROUNDUP: BIG APPROVALS, ICER INFLUENCE, DRUG-PRICE PUSHBACK & MORE

We'll start the roundup this week with two drug approvals that came late last Friday. Both were landmarks for the companies receiving...

GENETIC VARIANTS IN FAT‐ AND SHORT‐TAILED SHEEP FROM HIGH‐THROUGHPUT RNA‐SEQUENCING DATA

Animal Genetics, EarlyView.

 
 
 
Bio Roundup: Medicare Drug Prices, FDA Moves, Gene Therapy News & More

BIO ROUNDUP: MEDICARE DRUG PRICES, FDA MOVES, GENE THERAPY NEWS & MORE

Two imminent FDA rulings on two separate drugs aren't just noteworthy for the patients they'll help, but the long and winding road...