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Applications and Benefits of Single-Molecule Transcriptome Sequencing

APPLICATIONS AND BENEFITS OF SINGLE-MOLECULE TRANSCRIPTOME SEQUENCING

When looking to understand the functional implications of genetic variability, scientists should seek out the Iso-Seq method, according...

SABER TECH GIVES DNA AND RNA VISUALIZATION A BOOST

Researchers have been using "Fluorescence in situ hybridization" analysis for decades to literally fish for specific DNA and RNA sequences...

 
 
 

STRUCTURAL AND FUNCTIONAL MECHANISMS OF A NEW CLASS OF BACTERIAL SIGMA/ANTI-SIGMA FACTORS REVEALED

Transcription is the process of synthesizing messenger RNA by RNA polymerase based on the DNA sequence of a gene and is the initial...

Breakthrough Technique for Studying Gene Expression Takes Root in Plants

BREAKTHROUGH TECHNIQUE FOR STUDYING GENE EXPRESSION TAKES ROOT IN PLANTS

Researcher Christine Shulse tends to Arabidopsis plants in a lab at the DOE Joint Genome Institute. An open-source RNA analysis platform...

 
 
 

PROTEIN-ENSEMBLE-RNA DOCKING BY EFFICIENT CONSIDERATION OF PROTEIN FLEXIBILITY THROUGH HOMOLOGY MODELS

AbstractMotivationGiven the importance of protein-RNA interactions in many biological processes, a variety of docking algorithms have...

SENIOR RESEARCH ASSOCIATE, RNA PRODUCTION - ARCTURUS THERAPEUTICS - SAN DIEGO, CA

*About Us: * Founded in 2013 and based in San Diego, Arcturus Therapeutics Ltd. is a publicly traded RNA medicines company. We are...

 
 
 

CATCH A VIRUS BY ITS TAIL

Research uncovers key mechanism that allows some of the deadliest human RNA viruses to orchestrate the precise copying of the individual...

FACE-TIME WITH TAR: PORTRAITS OF AN HIV-1 RNA WITH DIVERSE MODES OF EFFECTOR RECOGNITION RELEVANT FOR DRUG DISCOVERY

Small molecules and short peptides that potently and selectively bind RNA are rare, making the molecular structures of these complexes...

 
 
 

SCRABBLE: SINGLE-CELL RNA-SEQ IMPUTATION CONSTRAINED BY BULK RNA-SEQ DATA

Single-cell RNA-seq data contain a large proportion of zeros for expressed genes. Such dropout events present a fundamental challenge...

NEW COMPUTATIONAL TOOL ENABLES POWERFUL MOLECULAR ANALYSIS OF BIOMEDICAL TISSUE SAMPLES

Single-cell RNA sequencing is emerging as a powerful technology in modern medical research, allowing scientists to examine individual...

 
 
 

ALTERNATIVE POLYADENYLATION COORDINATES EMBRYONIC DEVELOPMENT, SEXUAL DIMORPHISM AND LONGITUDINAL GROWTH IN XENOPUS TROPICALIS

Abstract RNA alternative polyadenylation contributes to the complexity of information transfer from genome to phenome, thus amplifying...

THE ROLE OF THE PROTEIN-RNA RECOGNITION CODE IN NEURODEGENERATION

Abstract MicroRNAs are small endogenous RNAs that pair and bind to sites on mRNAs to direct post-transcriptional repression. However,...

 
 
 

FASTQPURI: HIGH-PERFORMANCE PREPROCESSING OF RNA-SEQ DATA

RNA sequencing has become the standard means of analyzing gene and transcript expression in high-throughput. While previously sequence...

A NEW STRATEGY OF USING SATELLITE RNA TO CONTROL VIRAL PLANT DISEASES: POST‐INOCULATION WITH SATELLITE RNA ATTENUATES SYMPTOMS DERIVED FROM PRE‐INFECTION WITH ITS HELPER VIRUS

Abstract Satellite RNA is the supernumerary RNA of some viruses. It typically shares no nucleotide homology with its helper virus and...

 
 
 

TRANSLATION OF THE CIRCULAR RNA CIRCΒ-CATENIN PROMOTES LIVER CANCER CELL GROWTH THROUGH ACTIVATION OF THE WNT PATHWAY

Circular RNAs are a class of regulatory RNA transcripts, which are ubiquitously expressed in eukaryotes. In the current study, we evaluate...

 
 
 
Now Available: Sequel II System Delivers ~8 Times as Much Data as Previous System

NOW AVAILABLE: SEQUEL II SYSTEM DELIVERS ~8 TIMES AS MUCH DATA AS PREVIOUS SYSTEM

We're thrilled to announce the launch of the Sequel II System , reducing project costs and timelines with approximately eight times...

Arrakis spices up development efforts with $75M Series B round for RNA-targeting drugs

ARRAKIS SPICES UP DEVELOPMENT EFFORTS WITH $75M SERIES B ROUND FOR RNA-TARGETING DRUGS

The company has raised more than $100 million since 2017 and plans to use the current funding to build a pipeline of RNA-targeting...

 
 
 
Bio Roundup: Nationwide's Rise, a Surgeon's Quest, CRISPR USA & More

BIO ROUNDUP: NATIONWIDE'S RISE, A SURGEON'S QUEST, CRISPR USA & MORE

Persistence and perseverance were the themes of two of our top stories this week. First there's the story of Nationwide Children's...