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ARGININE METHYLATION OF TRANSLOCATED IN LIPOSARCOMA INHIBITS ITS BINDING TO LONG NONCODING RNA, ABROGATING TLS-MEDIATED REPRESSION OF CBP/P300 ACTIVITY

Translocated in liposarcoma is an RNA-binding protein and a transcription-regulatory sensor of DNA damage. TLS binds promoter-associated...

ANNOTATION TOOL PROVIDES STEP TOWARD UNDERSTANDING LINKS BETWEEN DISEASE, MUTANT RNA

Researchers have developed a computer program that represents a key step toward better understanding the connections between mutant...

 
 
 
Mysterious New RNA Strands may Help Colon Cancer Cells Survive

MYSTERIOUS NEW RNA STRANDS MAY HELP COLON CANCER CELLS SURVIVE

Colon cancer cells evade natural cell death process with new RNA strands, finds a new study. These RNA strands are also called long...

New CRISPR Startup from Feng Zhang Revealed

NEW CRISPR STARTUP FROM FENG ZHANG REVEALED

With all the buzz this week about the new CRISPR diagnostic startup from the University of California, Berkeley lab of Jennifer Doudna,...

 
 
 

WHAT HISTORY TELLS US XLV. THE ‘INSTABILITY' OF MESSENGER RNA

 
 
 
Agenda Posted for Xconomy's What's Hot in Boston Biotech on May 16

AGENDA POSTED FOR XCONOMY'S WHAT'S HOT IN BOSTON BIOTECH ON MAY 16

Join Xconomy next month for our sixth installment of What's Hot in Boston Biotech on May 16 at the Broad Institute of MIT and Harvard....

Maddie Willis IAmScience

MADDIE WILLIS IAMSCIENCE

Maddie Willis, a senior biochemistry major, works in the Burke Lab in Bond LSC. | photo by Allison Scott, Bond LSC By Allison Scott...

 
 
 
Arcturus Board Sues Ex-CEO, Alleges Deceit, in Prelude to Proxy Fight

ARCTURUS BOARD SUES EX-CEO, ALLEGES DECEIT, IN PRELUDE TO PROXY FIGHT

The board that fired Arcturus Therapeutics co-founder and CEO Joseph E. Payne earlier this year unleashed a new broadside this week...

SUPPA2: FAST, ACCURATE, AND UNCERTAINTY-AWARE DIFFERENTIAL SPLICING ANALYSIS ACROSS MULTIPLE CONDITIONS

Despite the many approaches to study differential splicing from RNA-seq, many challenges remain unsolved, including computing capacity...

 
 
 

THE RNA BINDING PROTEIN SORBS2 SUPPRESSES METASTATIC COLONIZATION OF OVARIAN CANCER BY STABILIZING TUMOR-SUPPRESSIVE IMMUNOMODULATORY TRANSCRIPTS

Ovarian cancer constitutes one of the most lethal gynecologic malignancies for females. Currently, early detection strategies and therapeutic...

TOTAL RNA EXTRACTION FROM TISSUES FOR MICRORNA AND TARGET GENE EXPRESSION ANALYSIS: NOT ALL KITS ARE CREATED EQUAL

MicroRNAs are short non-coding RNAs that fine-tune gene expression. The aberrant expression of miRNAs is associated with many diseases...

 
 
 

CRYO-EM STRUCTURE OF A MAMMALIAN RNA POLYMERASE II ELONGATION COMPLEX INHIBITED BY {ALPHA}-AMANITIN

RNA polymerase II is the central enzyme that transcribes eukaryotic protein-coding genes to produce mRNA. The mushroom toxin α-amanitin...

A New Look at an Old Favorite: Cabernet Sauvignon Study Generates a Transcriptome of Ripening Berries

A NEW LOOK AT AN OLD FAVORITE: CABERNET SAUVIGNON STUDY GENERATES A TRANSCRIPTOME OF RIPENING BERRIES

Photo by H. Zell A new preprint from scientists at the University of California, Davis, demonstrates the usefulness of SMRT Sequencing...

 
 
 
New Software, Polymerase for Sequel System Boost Throughput and Affordability

NEW SOFTWARE, POLYMERASE FOR SEQUEL SYSTEM BOOST THROUGHPUT AND AFFORDABILITY

Today we're pleased to announce the release of a new version of Sequel Software and a new polymerase. Combined, these upgrades increase...

Paying for Gene Therapy, CRISPR in People, RNAi at “What's Hot” on May 16

PAYING FOR GENE THERAPY, CRISPR IN PEOPLE, RNAI AT “WHAT'S HOT” ON MAY 16

A new age of medicine is underway, and we're only just beginning to grapple with the implications. The first U.S. gene therapy , for...

 
 
 

A NEW REGULATOR OF CELLULASE AND XYLANASE IN THE THERMOPHILIC FUNGUS MYCELIOPHTHORA THERMOPHILA STRAIN ATCC 42464

Abstract Myceliophthora thermophila is a thermophilic fungus that produces cellulolytic enzymes with high thermal stability. Unlike...

GENE EXPRESSION IN RETINAL ISCHEMIC POST-CONDITIONING

Abstract Purpose The pathophysiology of retinal ischemia involves mechanisms including inflammation and apoptosis. Ischemic post-conditioning...

 
 
 

OBSERVATION WEIGHTS UNLOCK BULK RNA-SEQ TOOLS FOR ZERO INFLATION AND SINGLE-CELL APPLICATIONS

Dropout events in single-cell RNA sequencing cause many transcripts to go undetected and induce an excess of zero read counts, leading...

Tracking RNA to Pinpoint Time of Death: Better Than Bugs?

TRACKING RNA TO PINPOINT TIME OF DEATH: BETTER THAN BUGS?

DNA is a persistent molecule. Genome sequencing is possible for creatures as ancient as mummies and mammoths. But the messenger RNA...