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Bio Roundup: Big Approvals, ICER Influence, Drug-Price Pushback & More

BIO ROUNDUP: BIG APPROVALS, ICER INFLUENCE, DRUG-PRICE PUSHBACK & MORE

We'll start the roundup this week with two drug approvals that came late last Friday. Both were landmarks for the companies receiving...

GENETIC VARIANTS IN FAT‐ AND SHORT‐TAILED SHEEP FROM HIGH‐THROUGHPUT RNA‐SEQUENCING DATA

Animal Genetics, EarlyView.

 
 
 
Bio Roundup: Medicare Drug Prices, FDA Moves, Gene Therapy News & More

BIO ROUNDUP: MEDICARE DRUG PRICES, FDA MOVES, GENE THERAPY NEWS & MORE

Two imminent FDA rulings on two separate drugs aren't just noteworthy for the patients they'll help, but the long and winding road...

 
 
 

ROLE OF MIRNAS IN HYPOXIA-RELATED DISORDERS

Abstract Hypoxia is a complex pathophysiological condition. The physiological and molecular responses to this stress have been extensively...

A MULTICOLOR RIBOSWITCH-BASED PLATFORM FOR IMAGING OF RNA IN LIVE MAMMALIAN CELLS

A multicolor riboswitch-based platform for imaging of RNA in live mammalian cells A multicolor riboswitch-based platform for imaging...

 
 
 

POSTTRANSCRIPTIONAL REGULATION OF CYCLIN D1 BY ARE-BINDING PROTEINS AUF1 AND HUR IN CYCLING MYOBLASTS

Abstract RNA binding proteins can regulate the stability and/or translatability of messengerRNAs through interactions with their 3′-untranslated...

Bio Roundup: Alnylam's Moment, Read on Rebates, Skinny Plans & More

BIO ROUNDUP: ALNYLAM'S MOMENT, READ ON REBATES, SKINNY PLANS & MORE

Millions of people might be on vacation as we hit the dog days, but drug makers and politicians aren't taking a break from the gamesmanship...

 
 
 

CHANGES TO SPERM'S SMALL RNA IN THE EPIDIDYMIS MAY HELP ENSURE MOUSE EMBRYOS IMPLANT

This week, Louise Brown, the first person born after conception by in vitro fertilization , celebrates her 40th birthday. Thanks to...

MATATAKI: AN ULTRAFAST MRNA QUANTIFICATION METHOD FOR LARGE-SCALE REANALYSIS OF RNA-SEQ DATA

Data generated by RNA sequencing is now accumulating in vast amounts in public repositories, especially for human and mouse genomes....

 
 
 
Maize Collaborators Embark on Ambitious 26-line Pangenome Project

MAIZE COLLABORATORS EMBARK ON AMBITIOUS 26-LINE PANGENOME PROJECT

Computational biologist Doreen Ware harvests maize tissue for RNA isolation. Photo by Miriam Chua c/o USDA The first reference genome...

BRAINEXP: A DATABASE FEATURING WITH SPATIOTEMPORAL EXPRESSION VARIATIONS AND CO-EXPRESSION ORGANIZATIONS IN HUMAN BRAINS

AbstractMotivationGene expression changes over the lifespan and varies among different tissues or cell types. Gene co-expression also...

 
 
 

PINGPONGPRO: A TOOL FOR THE DETECTION OF PIRNA-MEDIATED TRANSPOSON SILENCING IN SMALL RNA-SEQ DATA

AbstractSummaryPiwi-interacting RNAs are a class of small non-coding RNAs which guide endonucleases to mRNAs of actively transcribed...

GRANDPRIX: SCALING UP THE BAYESIAN GPLVM FOR SINGLE-CELL DATA

AbstractMotivationThe Gaussian Process Latent Variable Model is a popular approach for dimensionality reduction of single-cell data...

 
 
 

ORGANIZING A CELL'S GENETIC MATERIAL FROM THE SIDELINES

A tremendous amount of genetic material must be packed into the nucleus of every cell - a tiny compartment. One of the biggest challenges...

Skyhawk Lands $100M from Funding & Celgene Pact for RNA-Targeted Drugs

SKYHAWK LANDS $100M FROM FUNDING & CELGENE PACT FOR RNA-TARGETED DRUGS

Almost exactly a year ago, a Boston-area cancer immunotherapy startup led by Bill Haney announced its first partnership , with Celgene....

 
 
 

GENOME-WIDE GENE EXPRESSION PROFILES IN RESPONSE TO DOWNY MILDEW IN CHINESE CABBAGE

Abstracts Downy mildew caused by Hyaloperonospora brassicae is one of the most damaging diseases of Chinese cabbage. In this study,...

A TRANSCRIPTOMIC ANALYSIS OF SACCHAROMYCES CEREVISIAE UNDER THE STRESS OF 2-PHENYLETHANOL

Abstract 2-Phenylethanol is a kind of advanced aromatic alcohol with rose fragrance, which is wildly used for the deployment of flavors...

 
 
 

RNA SEQUENCING DATA FROM NEUTROPHILS OF PATIENTS WITH CYSTIC FIBROSIS REVEALS POTENTIAL FOR DEVELOPING BIOMARKERS FOR PULMONARY EXACERBATIONS

Publication date: Available online 23 June 2018 Author(s): Kaiyu Jiang, Kerry E. Poppenberg, Laiping Wong, Yanmin Chen, Drucy Borowitz,...

QUANTIFYING TUMOR-INFILTRATING IMMUNE CELLS FROM TRANSCRIPTOMICS DATA

Abstract By exerting pro- and anti-tumorigenic actions, tumor-infiltrating immune cells can profoundly influence tumor progression,...