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New High-Resolution Genome Assemblies Expand Our Understanding of Human-Ape Differences

NEW HIGH-RESOLUTION GENOME ASSEMBLIES EXPAND OUR UNDERSTANDING OF HUMAN-APE DIFFERENCES

Ever since researchers sequenced the chimpanzee genome in 2005, they have known that humans share the vast majority of our DNA sequence...

IMPROVED DESIGN AND ANALYSIS OF CRISPR KNOCKOUT SCREENS

AbstractMotivationGenome-wide CRISPR-Cas9 screen has been widely used to interrogate gene functions. However, the rules to design better...

 
 
 

UNIVERSAL EVOLUTIONARY SELECTION FOR HIGH DIMENSIONAL SILENT PATTERNS OF INFORMATION HIDDEN IN THE REDUNDANCY OF VIRAL GENETIC CODE

AbstractMotivationUnderstanding how viruses co-evolve with their hosts and adapt various genomic level strategies in order to ensure...

Bio-IT World: Genomic Data Standards Are a ‘Necessity'

BIO-IT WORLD: GENOMIC DATA STANDARDS ARE A ‘NECESSITY'

Aaron Wenger, Ph.D Genomic data standards will be essential for continuing the growth of genomics and ensuring its smooth transition...

 
 
 
National Nutrition Month: The Promise of Gene Editing

NATIONAL NUTRITION MONTH: THE PROMISE OF GENE EDITING

One of the leading voices at the intersection of cooking and nutrition is Monica Reinagel or, as active social media users might know...

THE COMPLETE CHLOROPLAST GENOME OF TAIWANIA CRYPTOMERIOIDES , AN ENDANGERED RELICT CONIFER SPECIES ENDEMIC TO EAST ASIA

Abstract Taiwania cryptomerioides is an endangered relict conifer species native to East Asia with a variety of practical applications....

 
 
 

INDUCTION AND RECOVERY OF COPY NUMBER VARIATION IN BANANA THROUGH GAMMA IRRADIATION AND LOW COVERAGE WHOLE GENOME SEQUENCING

Summary Traditional breeding methods are hindered in bananas due to the fact that major cultivars are sterile, parthenocarpic, triploid,...

Imaging Flexible DNA ‘Building Blocks' in 3-D

IMAGING FLEXIBLE DNA ‘BUILDING BLOCKS' IN 3-D

A collection of 120 3-D images of Bennett linkages. The images were created using individual-particle electron tomography , a technique...

 
 
 

MULTIOBJECTIVE MULTIFACTOR DIMENSIONALITY REDUCTION TO DETECT SNP-SNP INTERACTIONS

AbstractMotivationSingle-nucleotide polymorphism -SNP interactions are popular markers for understanding disease susceptibility. Multifactor...

BIOCHEMICAL CHARACTERIZATION OF THE ENGINEERED SOLUBLE PHOTOACTIVATED GUANYLATE CYCLASES FROM MICROBES EXPANDS OPTOGENETIC TOOLS

Abstract Cyclic nucleotide, such as cyclic GMP, is a secondary messenger that regulates a wide range of biological process via the...

 
 
 

SPEXIN IN THE HALF-SMOOTH TONGUE SOLE : MOLECULAR CLONING, EXPRESSION PROFILES, AND PHYSIOLOGICAL EFFECTS

Abstract Spexin , a novel neuropeptide discovered by the bioinformatics approach, has been shown to exert pleiotropic functions in...

PARTIAL DNA-GUIDED CAS9 ENABLES GENOME EDITING WITH REDUCED OFF-TARGET ACTIVITY

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity Partial DNA-guided Cas9 enables genome editing with...

 
 
 
SOLVE-RD Funded to Improve Diagnosis of Rare Disease with New Tools Including Long-Read Sequencing

SOLVE-RD FUNDED TO IMPROVE DIAGNOSIS OF RARE DISEASE WITH NEW TOOLS INCLUDING LONG-READ SEQUENCING

The SOLVE-RD research program , a collaboration of 21 participant organizations in 10 nations, announced it has received a €15 million...

DISCOVERING THE STRUCTURE OF RNA

A research team has developed a computerized simulation model which can effectively predict the three-dimensional conformation of the...

 
 
 

'SILENT CODE' OF NUCLEOTIDES, NOT AMINO ACIDS, DETERMINES FUNCTIONS OF VITAL PROTEINS

Humans possess six forms of the protein actin, which perform essential functions in the body. Two in particular, ?-actin and ?-actin,...

GENETIC VARIATION ASSOCIATED WITH HEALTHY TRAITS AND ENVIRONMENTAL CONDITIONS IN VACCINIUM VITIS-IDAEA

Abstract Background Lingonberry , one of the least studied fruit crops in the Ericaceae family, has a dramatically increased worldwide...

 
 
 
Creating an Epigenetic Barcode to Accurately Characterize Microbial Communities

CREATING AN EPIGENETIC BARCODE TO ACCURATELY CHARACTERIZE MICROBIAL COMMUNITIES

Unraveling the role of the microbiome in human health and environmental samples is an emerging priority in scientific study. But despite...

MOAT: EFFICIENT DETECTION OF HIGHLY MUTATED REGIONS WITH THE MUTATIONS OVERBURDENING ANNOTATIONS TOOL

AbstractSummaryIdentifying genomic regions with higher than expected mutation count is useful for cancer driver detection. Previous...

 
 
 
The Zebrafish Farm

THE ZEBRAFISH FARM

Aquariums are arranged in neat, illuminated rows. Fins, tails and flashing stripes are visible in every direction. On the Mayo Clinic...

MYCOBACTERIUM TUBERCULOSIS UVRB FORMS DIMERS IN SOLUTION AND INTERACTS WITH UVRA IN THE ABSENCE OF LIGANDS

Abstract During its life cycle Mycobacterium tuberculosis must face a variety of environmental and endogenous physical and chemical...