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NEXT‐GENERATION SEQUENCING IDENTIFIED GENOMIC REGION AND DIAGNOSTIC MARKERS FOR RESISTANCE TO BACTERIAL WILT ON CHROMOSOME B02 IN PEANUT

Abstract Bacterial wilt, caused by Ralstonia solanacearum, is a devastating disease affecting over 350 plant species. A few peanut...

FACE-TIME WITH TAR: PORTRAITS OF AN HIV-1 RNA WITH DIVERSE MODES OF EFFECTOR RECOGNITION RELEVANT FOR DRUG DISCOVERY

Small molecules and short peptides that potently and selectively bind RNA are rare, making the molecular structures of these complexes...

 
 
 

THE ROLE OF THE PROTEIN-RNA RECOGNITION CODE IN NEURODEGENERATION

Abstract MicroRNAs are small endogenous RNAs that pair and bind to sites on mRNAs to direct post-transcriptional repression. However,...

A NEW STRATEGY OF USING SATELLITE RNA TO CONTROL VIRAL PLANT DISEASES: POST‐INOCULATION WITH SATELLITE RNA ATTENUATES SYMPTOMS DERIVED FROM PRE‐INFECTION WITH ITS HELPER VIRUS

Abstract Satellite RNA is the supernumerary RNA of some viruses. It typically shares no nucleotide homology with its helper virus and...

 
 
 
Now Available: Sequel II System Delivers ~8 Times as Much Data as Previous System

NOW AVAILABLE: SEQUEL II SYSTEM DELIVERS ~8 TIMES AS MUCH DATA AS PREVIOUS SYSTEM

We're thrilled to announce the launch of the Sequel II System , reducing project costs and timelines with approximately eight times...

A COMPARATIVE SURVEY OF MICROSATELLITES AMONG WILD AND DOMESTIC CAT PROVIDES VALUABLE RESOURCES FOR MARKER DEVELOPMENT

Abstract Information on the level and distribution of genetic variation is important for conservation plan of captive population of...

 
 
 

IDENTIFICATION OF NOVEL MIRNAS AND THEIR TARGET GENES FROM POPULUS SZECHUANICA INFECTED WITH MELAMPSORA LARICI-POPULINA

Abstract Two novel miRNAs were selected from a pre-constructed RNA library of Populus szechuanica infected with the foliar rust fungus...

CYTOLOGY AND MOLECULAR STUDY FOR GSTP1 EFFECT ON ASTHMA IRAQI PATIENTS

Abstract Background GST belongs to a super family of phase II detoxification enzyme and it plays an important role in preventing the...

 
 
 

ENHANCED CHO CLONE SCREENING: APPLYING TARGETED LOCUS AMPLIFICATION AND NEXT‐GENERATION SEQUENCING TECHNOLOGIES DURING CELL LINE DEVELOPMENT

Abstract Early analytical clone screening is important during CHO cell line development of biotherapeutic antibodies to select clones...

A SINGLE NUCLEOTIDE MUTATION IN GID1C DISRUPTS ITS INTERACTION WITH DELLA1 AND CAUSES A GA‐INSENSITIVE DWARF PHENOTYPE IN PEACH

Summary Plant stature is one important factor that affects the productivity of peach orchards. However, little is known about the molecular...

 
 
 

DISSOCIATION MECHANISM OF GDP FROM CDC42 VIA DOCK9 REVEALED BY MOLECULAR DYNAMICS SIMULATIONS

Cell division control protein 42 homolog influences a variety of cellular responses such as cell migration and polarity. Deregulation...

EVOLUTIONARILY SIGNIFICANT A-TO-I RNA EDITING EVENTS ORIGINATED THROUGH G-TO-A MUTATIONS IN PRIMATES

Abstract Background Recent studies have revealed thousands of A-to-I RNA editing events in primates, but the origination and general...

 
 
 

DEVELOPMENT OF AN INTEGRATED 200K SNP GENOTYPING ARRAY AND APPLICATION FOR GENETIC MAPPING, GENOME ASSEMBLY IMPROVEMENT AND GWAS IN PEAR

Summary Pear , the third most important temperate fruit crop, has great nutritional and economic value. Despite the availability of...

RETROPHYLOGENOMICS IN RORQUALS INDICATE LARGE ANCESTRAL POPULATION SIZES AND A RAPID RADIATION

Abstract Background Baleen whales are the largest animals on earth and their evolutionary history has been studied in detail, but some...

 
 
 

TRANSCRIPTOMIC SIGNATURE REVEALS MECHANISM OF FLOWER BUD DISTORTION IN WITCHES'-BROOM DISEASE OF SOYBEAN

Abstract Background Soybean crop is major source of edible oil and protein for human and animals besides its various industrial uses...

INTERACTION BETWEEN TP53 AND XRCC1 INCREASES SUSCEPTIBILITY TO CERVICAL CANCER DEVELOPMENT: A CASE CONTROL STUDY

Abstract Background Cervical cancer is the 4th highest cause of female reproductive tract malignancies. Multiple loci have been identified...

 
 
 

THE DNA WALK AND ITS DEMONSTRATION OF DETERMINISTIC CHAOS- RELEVANCE TO GENOMIC ALTERATIONS IN LUNG CANCER

AbstractMotivationAdvancements in cancer genetics have facilitated the development of therapies with actionable mutations. Although...

SEQCLONE: SEQUENTIAL MONTE CARLO BASED INFERENCE OF TUMOR SUBCLONES

Tumor samples are heterogeneous. They consist of varying cell populations or subclones and each subclone is characterized with a distinct...

 
 
 

MIRNA-27A-3P AND MIRNA-222-3P AS NOVEL MODULATORS OF PHOSPHODIESTERASE 3A IN CEREBRAL MICROVASCULAR ENDOTHELIAL CELLS

Abstract Endothelial dysfunction is a key element in cerebral small vessel disease , which may cause stroke and cognitive decline....

MOLECULAR CHARACTERIZATION OF THE GARLIC VIRUS B GENOME AND EVIDENCE OF ALLEXIVIRUS RECOMBINATION

Abstract Molecular characterization is important for differentiating allexiviruses species, since detection by serological methods...