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Bioinformatic Identification of Chinese Hamster Ovary Cold‐Shock Genes and Biological Evidence of their Cold‐Inducible Promoters

BIOINFORMATIC IDENTIFICATION OF CHINESE HAMSTER OVARY COLD‐SHOCK GENES AND BIOLOGICAL EVIDENCE OF THEIR COLD‐INDUCIBLE PROMOTERS

Cold‐inducible promoters of high strength were identified based on a bioinformatic pipeline and extensively characterized in vivo....

NEW CRISPR-BASED SYSTEM TARGETS AMPLIFIED ANTIBIOTIC-RESISTANT GENES

Taking advantage of powerful advances in CRISPR gene editing, scientists at the University of California San Diego have set their sights...

 
 
 

COLORECTAL CANCER IN LYNCH SYNDROME ASSOCIATED WITH PMS2 AND MSH6 MUTATIONS

Abstract Background It is known that colorectal cancers are frequently seen and constitute an important part of cancer-related deaths....

TEMPORAL VEGFA RESPONSIVE GENES IN HUVECS: GENE SIGNATURES AND POTENTIAL LIGANDS/RECEPTORS FINE-TUNING ANGIOGENESIS

Abstract Vascular Endothelial Growth Factor-A signaling is crucial to the cellular processes involved in angiogenesis. Previously,...

 
 
 

THE IMPACT OF PSRC1 OVEREXPRESSION ON GENE AND TRANSCRIPT EXPRESSION PROFILING IN THE LIVERS OF APOE −/− MICE FED A HIGH-FAT DIET

Abstract Our previous studies have confirmed that proline/serine-rich coiled-coil 1 overexpression can regulate blood lipid levels...

CTCF MODULATES ALLELE-SPECIFIC SUB-TAD ORGANIZATION AND IMPRINTED GENE ACTIVITY AT THE MOUSE DLK1-DIO3 AND IGF2-H19 DOMAINS

Genomic imprinting is essential for mammalian development and provides a unique paradigm to explore intra-cellular differences in chromatin...

 
 
 

SEASONAL VARIABILITY OF CONDITIONALLY RARE TAXA IN THE WATER COLUMN BACTERIOPLANKTON COMMUNITY OF SUBTROPICAL RESERVOIRS IN CHINA

Abstract Conditionally rare bacteria are ubiquitous and perhaps the most diverse of microbial lifeforms, but their temporal dynamics...

MiRagen Restructures to Focus on Fibrosis, Inks $20M Stock Deal

MIRAGEN RESTRUCTURES TO FOCUS ON FIBROSIS, INKS $20M STOCK DEAL

MicroRNA therapies developer miRagen Therapeutics is scaling back work on its most advanced cancer drug candidate and shifting resources...

 
 
 

DNA METHYLATION DATA BY SEQUENCING: EXPERIMENTAL APPROACHES AND RECOMMENDATIONS FOR TOOLS AND PIPELINES FOR DATA ANALYSIS

Abstract Sequencing technologies have changed not only our approaches to classical genetics, but also the field of epigenetics. Specific...

Many mental health disorders are linked to the same 100 genes

MANY MENTAL HEALTH DISORDERS ARE LINKED TO THE SAME 100 GENES

Massachusetts General Hospital scientists have identified 109 gene variants that with shared links in more than one psychiatric disorder,...

 
 
 

HERPES'S ACHILLES HEEL

Scientists have used the gene-editing tool CRISPR-Cas9 to disrupt both latent reservoirs of the herpes simplex virus and actively replicating...

EVALUATION OF MDR1 AND MRPA GENES EXPRESSION IN DIFFERENT TYPES OF DRY CUTANEOUS LEISHMANIASIS

Abstract Objective The resistance to antimony-containing glucantime is a major obstacle to successful treatment, especially in endemic...

 
 
 

HNRNPK PROMOTES GASTRIC TUMORIGENESIS THROUGH REGULATING CD44E ALTERNATIVE SPLICING

Abstract Background The high prevalence of alternative splicing among genes implies the importance of genomic complexity in regulating...

HOPKINS TEAM INVENTS NON-VIRAL SYSTEM FOR GETTING GENE THERAPY INTO CELLS

Posted on: 12 December 2019, One of the most popular methods for inserting therapeutic genes into cells to treat disease is to transport...

 
 
 

LACK OF ASSOCIATION BETWEEN INTERLEUKIN-22 GENE POLYMORPHISMS AND CANCER RISK: A CASE-CONTROL STUDY AND A META-ANALYSIS

Abstract Background Interleukin-22 has been implicated in inflammation and tumorigenesis. The association between IL22 gene polymorphisms...

A SIMPLE AND RAPID DIAGNOSTIC METHOD TO DETECT NEW GOOSE ASTROVIRUS USING REVERSE-TRANSCRIPTION LOOP-MEDIATED ISOTHERMAL AMPLIFICATION

Abstract In this study, we develop a reverse-transcription loop-mediated isothermal amplification assay for rapid and easy detection...

 
 
 
Long-Read Sequencing Could Improve the Sensitivity and Precision of 16S Sequencing Says Jackson Lab Study

LONG-READ SEQUENCING COULD IMPROVE THE SENSITIVITY AND PRECISION OF 16S SEQUENCING SAYS JACKSON LAB STUDY

It's time to revisit the way scientists are using 16S rRNA gene sequencing to study microorganisms, according to a team of Jackson...

VACCINATION OF MICE WITH A RECOMBINANT NOVEL CATHEPSIN B INHIBITS TRICHINELLA SPIRALIS DEVELOPMENT, REDUCES THE FECUNDITY AND WORM BURDEN

Abstract Background Trichinella spiralis is a major zoonotic tissue-dwelling nematode, which is a public health concern and a serious...

 
 
 

A NEW METHOD FOR QUANTITATIVE DETECTION OF LACTOBACILLUS CASEI BASED ON CASX GENE AND ITS APPLICATION

The traditional method of bacterial identification based on 16S rRNA is a widely used and very effective detection method, but this...

WNT/Β-CATENIN SIGNALLING IN OVARIAN CANCER: INSIGHTS INTO ITS HYPERACTIVATION AND FUNCTION IN TUMORIGENESIS

Abstract Epithelial ovarian cancer is the deadliest female malignancy. The Wnt/β-catenin pathway plays critical roles in regulating...