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HOW DOES A CELL MAINTAIN ITS IDENTITY DURING REPLICATION?

Prior to cell division, chromosomes are seemingly a jumbled mess. During cell division, parent cell chromosomes and their duplicates...

New Insights in Soil Ecology: SMRT Sequencing Powers Genome Assembly of Parthenogenetic Arthropod

NEW INSIGHTS IN SOIL ECOLOGY: SMRT SEQUENCING POWERS GENOME ASSEMBLY OF PARTHENOGENETIC ARTHROPOD

Photo by Andy Murray In a recent BMC Genomics paper, scientists in the Netherlands report a high-quality genome assembly for Folsomia...

 
 
 

CHROMOSOME CONTACTS IN ACTIVATED T CELLS IDENTIFY AUTOIMMUNE DISEASE CANDIDATE GENES

Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking...

GROWTH RATE CHANGES IN CHO HOST CELLS ARE ASSOCIATED WITH KARYOTYPIC HETEROGENEITY

Chinese hamster ovary cell line instability and clonality issues can affect cell culture phenotypes such as cell growth, productivity,...

 
 
 

HOW HEAD-ON COLLISIONS OF DNA PROTEIN MACHINES STOP REPLICATION

Head-on collisions between the protein machines that crawl along chromosomes can disrupt DNA replication and boost gene mutation rates....

In Bake-Off, SMRT Sequencing Generates Highest-Quality, Cost-Effective Bacterial Assembly

IN BAKE-OFF, SMRT SEQUENCING GENERATES HIGHEST-QUALITY, COST-EFFECTIVE BACTERIAL ASSEMBLY

From CDC/Courtesy of Larry Stauffer, Oregon State Public Health Laboratory Scientists from the University of Hong Kong recently reported...

 
 
 
One Common Genetic Variant in Chromosome 6p24 Linked to Five Vascular Diseases

ONE COMMON GENETIC VARIANT IN CHROMOSOME 6P24 LINKED TO FIVE VASCULAR DISEASES

A SNP called rs9349379, located hundreds of kilobases away, was the strongest risk factor for cardiovascular disease at chromosome...

NO GENE IS AN ISLAND

Genes do not exist in isolation. Like beads on a string, they sit next to each other on the chromosomes. So far, little has been known...

 
 
 
New Assembly for Complex Bread Wheat Genome: 10 Times Higher Contiguity

NEW ASSEMBLY FOR COMPLEX BREAD WHEAT GENOME: 10 TIMES HIGHER CONTIGUITY

Photo by Max Ronnersjö In a new bioRxiv preprint, scientists from Johns Hopkins present a major step forward in accuracy and completeness...

A Whole-Genome Sequenced Rice Mutant Resource for the Study of Biofuel Feedstocks

A WHOLE-GENOME SEQUENCED RICE MUTANT RESOURCE FOR THE STUDY OF BIOFUEL FEEDSTOCKS

By Greta Lorge Rice is a staple food for over half of the world's population and a model for studies of candidate bioenergy grasses...

 
 
 

HUMAN LONGEVITY, INC. RESEARCHERS DEVELOP NEW ALGORITHM TO RAPIDLY AND ACCURATELY PREDICT HLA TYPES USING ILLUMINA NEXT GENERATION SEQUENCING TECHNOLOGY

SAN DIEGO, July 3, 2017 /PRNewswire/ - Researchers from Human Longevity, Inc. have developed a new algorithm called xHLA to rapidly...

HOW TELOMERES PROTECT CELLS FROM PREMATURE SENESCENCE

Researchers have further uncovered the secrets of telomeres, the caps that protect the ends of our chromosomes. They discovered that...

 
 
 
Iso-Seq Data Supports Annotation Efforts for Key Crops Wheat and Barley

ISO-SEQ DATA SUPPORTS ANNOTATION EFFORTS FOR KEY CROPS WHEAT AND BARLEY

Photo by Craig Nagy Two recent papers underscore the importance of using PacBio full-length RNA sequencing to interrogate transcriptomes...

Here's How the Immune System Helps Combat Chromosome Imbalance

HERE'S HOW THE IMMUNE SYSTEM HELPS COMBAT CHROMOSOME IMBALANCE

The immune system uses a mechanism that might provide a clearance of cells with imbalanced chromosome numbers. This mechanism may be...

 
 
 
Smart blood test can show whether lung cancer will return

SMART BLOOD TEST CAN SHOW WHETHER LUNG CANCER WILL RETURN

Experts at the Francis Crick Institute in London found unstable chromosomes within lung cancer cells dramatically increased the risk...

“SET IN STONE” OR “RAY OF HOPE”: PARENTS' BELIEFS ABOUT CAUSE AND PROGNOSIS AFTER GENOMIC TESTING OF CHILDREN DIAGNOSED WITH ASD

Abstract Despite increasing utilization of chromosomal microarray analysis for autism spectrum disorders , limited information exists...

 
 
 

A NEW LOCATION TO SPLIT CRE RECOMBINASE FOR PROTEIN FRAGMENT COMPLEMENTATION

Summary We have previously described a recombinase-mediated gene stacking system in which the Cre recombinase is used to remove lox...

VISUALIZING THE GENOME: FIRST 3-D STRUCTURES OF ACTIVE DNA CREATED

Scientists have determined the first 3-D structures of intact mammalian genomes from individual cells, showing how the DNA from all...

 
 
 
With Synthetic Biology Software, Geneticists Design Living Organisms From Scratch

WITH SYNTHETIC BIOLOGY SOFTWARE, GENETICISTS DESIGN LIVING ORGANISMS FROM SCRATCH

Project that aims to build a synthetic yeast pioneers the design and debugging of chromosomes

Saving GINA: Is Genetic Privacy Imperiled?

SAVING GINA: IS GENETIC PRIVACY IMPERILED?

A bill that passed its first hurdle yesterday in Congress threatens to take away genetic privacy protections put in place with the...