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EX VIVO EVOLUTION OF HUMAN ANTIBODIES BY CRISPR-X: FROM A NAIVE B CELL REPERTOIRE TO AFFINITY MATURED ANTIBODIES

CRISPR CORRECTS DMD IN MICE FOR A YEAR IN SAREPTA-SUPPORTED STUDY

A Duke lab at the center of a research pact with Sarepta is reporting promising results from a trial of CRISPR gene editing in mouse...

 
 
 
Bio Roundup: New CRISPR Feud, A NY Splash, Pharma vs. Congress & More

BIO ROUNDUP: NEW CRISPR FEUD, A NY SPLASH, PHARMA VS. CONGRESS & MORE

If you're into congressional spectacles, stay tuned later this month. A group of top biopharma executives-the full roster isn't known...

LECITHIN NANO-LIPOSOMAL PARTICLE AS A CRISPR/CAS9 COMPLEX DELIVERY SYSTEM FOR TREATING TYPE 2 DIABETES

Protein-based Cas9 in vivo gene editing therapeutics have practical limitations owing to their instability and low efficacy. To overcome...

 
 
 

MULTIPLE-GENE TARGETING AND MISMATCH TOLERANCE CAN CONFOUND ANALYSIS OF GENOME-WIDE POOLED CRISPR SCREENS

Genome-wide loss-of-function screens using the CRISPR/Cas9 system allow the efficient discovery of cancer cell vulnerabilities. While...

JOHN INNES CENTRE APPLIES FOR GM WHEAT, CRISPR BRASSICA FIELD TRIALS

A team of researchers at the John Innes Centre headed by Prof. Cristobal Uauy has applied for consent to conduct field trials of genetically...

 
 
 
Editas CEO Katrine Bosley to Depart on Cusp of CRISPR Clinical Trial

EDITAS CEO KATRINE BOSLEY TO DEPART ON CUSP OF CRISPR CLINICAL TRIAL

Editas Medicine has the regulatory blessing to test its experimental gene-editing therapy in humans, and a $25 million check from its...

SCIENTISTS DEMONSTRATE EFFECTIVE STRATEGIES FOR SAFEGUARDING CRISPR GENE-DRIVE EXPERIMENTS

Researchers have demonstrated for the first time how two molecular strategies can safeguard CRISPR gene-drive experiments in the lab,...

 
 
 
Bio Roundup: $74B for Celgene, Two CAR-T Tales, Ready for SF & More

BIO ROUNDUP: $74B FOR CELGENE, TWO CAR-T TALES, READY FOR SF & MORE

In 2018, my Exome colleagues and I published hundreds of stories about health, medicine, the biopharma industry, government policy,...

 
 
 

SINGLE TRANSCRIPT UNIT CRISPR 2.0 SYSTEMS FOR ROBUST CAS9 AND CAS12A MEDIATED PLANT GENOME EDITING

Abstract CRISPR‐Cas9 and Cas12a are two powerful genome editing systems. Expression of CRISPR in plants is typically achieved with...

China's gene-edited babies experiment violated western ethics norms. But China is writing is own

CHINA'S GENE-EDITED BABIES EXPERIMENT VIOLATED WESTERN ETHICS NORMS. BUT CHINA IS WRITING IS OWN

Mark Schiefelbein/AP Photo Chinese scientist He Jiankui shocked the world with his recent claim that he modified the genes of two babies. However,...

 
 
 
15 For '19: Key Clinical Data to Watch For Next Year

15 FOR '19: KEY CLINICAL DATA TO WATCH FOR NEXT YEAR

On Monday, Xconomy began our annual look ahead at clinical trials that could define biotech and have profound healthcare effects in...

Bio Roundup: Eli Lilly Tries Tau, Generic Insulin, NASH Cash & More

BIO ROUNDUP: ELI LILLY TRIES TAU, GENERIC INSULIN, NASH CASH & MORE

Pharmaceutical industry critics lament the cost of rare disease drugs, but some of the steepest price hikes have come on widely used...

 
 
 
Companies tracking mutations in cancer cells can provide a key to unlocking better therapies

COMPANIES TRACKING MUTATIONS IN CANCER CELLS CAN PROVIDE A KEY TO UNLOCKING BETTER THERAPIES

Investors and entrepreneurs are beginning to bring new diagnostic tools to market that promise better results for cancer patients through...

News of the first gene-edited babies shows that science can't police itself

NEWS OF THE FIRST GENE-EDITED BABIES SHOWS THAT SCIENCE CAN'T POLICE ITSELF

Just over a year ago, CRISPR pioneer Jennifer Doudna of UC Berkeley talked with me about the prospects that the gene-editing technology...

 
 
 

CRISPR-BASED HEART TEST PINPOINTS GENETIC RISK FOR SEVERE CARDIOMYOPATHY

Severe hypertrophic cardiomyopathy, a dangerous disorder that causes an abnormal thickening of the heart walls is often associated...

 
 
 

CRISPR BABIES RAISE AN UNCOMFORTABLE REALITY - ABIDING BY SCIENTIFIC STANDARDS DOESN'T GUARANTEE ETHICAL RESEARCH

Uncertainty continues to swirl around scientist He Jiankui's gene editing experiment in China. Using CRISPR technology, He modified...