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Vertex CF Competitor Proteostasis Falters, Galapagos Up Next

VERTEX CF COMPETITOR PROTEOSTASIS FALTERS, GALAPAGOS UP NEXT

Data released Wednesday afternoon looks to have eased a potential threat to Vertex Pharmaceuticals' burgeoning cystic fibrosis franchise,...

PRIMARY SCLEROSING CHOLANGITIS IS ASSOCIATED WITH ABNORMALITIES IN CFTR

Publication date: Available online 26 May 2018 Author(s): Steven Werlin, Virginie Scotet, Kevin Uguen, Marie-Pierre Audrezet, Michael...

 
 
 
CFTR rescue with VX-809 and VX-770 favors the repair of primary airway epithelial cell cultures from patients with class II mutations in the presence of Pseudomonas aeruginosa exoproducts

CFTR RESCUE WITH VX-809 AND VX-770 FAVORS THE REPAIR OF PRIMARY AIRWAY EPITHELIAL CELL CULTURES FROM PATIENTS WITH CLASS II MUTATIONS IN THE PRESENCE OF PSEUDOMONAS AERUGINOSA EXOPRODUCTS

Publication date: Available online 13 April 2018 Author(s): Damien Adam, Claudia Bilodeau, Laura Sognigbé, Émilie Maillé, Manon Ruffin,...

Comparison of ex vivo and in vitro intestinal cystic fibrosis models to measure CFTR-dependent ion channel activity

COMPARISON OF EX VIVO AND IN VITRO INTESTINAL CYSTIC FIBROSIS MODELS TO MEASURE CFTR-DEPENDENT ION CHANNEL ACTIVITY

Publication date: Available online 13 March 2018 Author(s): Domenique D. Zomer-van Ommen, Eyleen de Poel, Evelien Kruisselbrink, Hugo...

 
 
 

PROTEIN AND LIPID INTERACTIONS - MODULATING CFTR TRAFFICKING AND RESCUE

Publication date: March 2018 Author(s): Carlos M. Farinha, Elizabeth Miller, Nael McCarty Different levels of CFTR regulation in the...

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR-EMERGING REGULATOR OF CANCER

Abstract Mutations of cystic fibrosis transmembrane conductance regulator cause cystic fibrosis, the most common life-limiting recessive...

 
 
 

ANALYTICAL AND BIOLOGICAL VARIATION IN REPEATED SWEAT CHLORIDE CONCENTRATIONS IN CLINICAL TRIALS FOR CFTR MODULATOR THERAPY

Publication date: Available online 22 July 2017 Author(s): V.A. LeGrys, T.C. Moon, J. Laux, M.J. Rock, F. Accurso Background Using...

Vertex Touts Positive Triple-Drug Data For Cystic Fibrosis Patients

VERTEX TOUTS POSITIVE TRIPLE-DRUG DATA FOR CYSTIC FIBROSIS PATIENTS

Vertex Pharmaceuticals continued its march away from being the biggest loser in the hepatitis C wars and toward increasing dominance...

 
 
 
Cystic Fibrosis Among Asians: Why Ethnicity-Based Genetic Testing is Obsolete

CYSTIC FIBROSIS AMONG ASIANS: WHY ETHNICITY-BASED GENETIC TESTING IS OBSOLETE

A hypothetical heterosexual couple living in the US or UK takes tests to learn if they are carriers of the more prevalent recessive...

 
 
 

CFTR NONSENSE MUTATIONS: THERAPEUTIC BENEFITS FROM CLINICALLY APPROVED DRUGS?

Publication date: Available online 10 December 2016 Author(s): J. Kevin Foskett