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THE EFFECTS OF SOMATIC MUTATIONS ON EGFR INTERACTION WITH ANTI‐EGFR MONOCLONAL ANTIBODIES: IMPLICATION FOR ACQUIRED RESISTANCE

Abstract A number of mutations in the EGFR have been identified that imparts resistance to anti‐EGFR monoclonal antibodies in clinical...

ASTRAZENECA SPINOUT VIELA BAGS $75M AS FDA FILING NEARS

AstraZeneca spinout Viela Bio has raised $75 million to take anti-CD19 antibody inebilizumab toward approval. The series B round comes...

 
 
 

IN VITRO AND IN VIVO EFFICACY OF ANTI‐CHIKUNGUNYA VIRUS MONOCLONAL ANTIBODIES PRODUCED IN WILD‐TYPE AND GLYCOENGINEERED N. BENTHAMIANA PLANTS

Abstract Chikungunya virus is a mosquito‐transmitted alphavirus and its infection can cause long‐term debilitating arthritis in humans....

Viral Antibodies Found Years Before Throat Cancer Diagnosis

VIRAL ANTIBODIES FOUND YEARS BEFORE THROAT CANCER DIAGNOSIS

Antibodies against HPV16 can develop from six to 40 years before throat cancer is diagnosed, according to a new study.

 
 
 

KINETIC MODELLING AS A TOOL TO UNDERSTAND THE INFLUENCE OF CELL CULTURE PROCESS PARAMETERS ON THE GLYCATION OF MONOCLONAL ANTIBODY BIOTHERAPEUTICS

ABSTRACT Glycation, the non‐enzymatic reaction between the reducing sugar glucose and the primary amine residues on amino‐acid side‐chains,...

LECTIN BIO‐LAYER INTERFEROMETRY FOR ASSESSING PRODUCT QUALITY OF FC‐ GLYCOSYLATED IMMUNOGLOBULIN G

Abstract Glycosylation, as the most prominent post‐translational modification, is recognized as an important quality attribute of monoclonal...

 
 
 

PROGRESS AND CHALLENGES IN HER2-POSITIVE GASTROESOPHAGEAL ADENOCARCINOMA

HER2 expression remains an important biomarker to guide the addition of the monoclonal antibody trastuzumab to first-line systemic...

GENMAB FILES FOR $500M IPO TO FUND MULTI-FRONT CANCER R&D PUSH

Genmab has filed to raise up to $500 million in an IPO on the Nasdaq. The huge offering will set Genmab up to take antibody-drug conjugate...

 
 
 

SCIENTIST: IMMUNO-ONCOLOGY - AVANTGEN - SAN DIEGO, CA

AvantGen is a San Diego-based biotech company focusing on the discovery and development of novel antibody-based therapeutics with its...

SUITABILITY OF A GENERIC VIRUS SAFETY EVALUATION FOR MONOCLONAL ANTIBODY INVESTIGATIONAL NEW DRUG APPLICATIONS

Abstract Biologics produced from CHO cell lines with endogenous virus DNA can produce retrovirus‐like particles in cell culture at...

 
 
 

HYBRID OPTIMIZATION OF PREPARATIVE CHROMATOGRAPHY FOR A TERNARY MONOCLONAL ANTIBODY MIXTURE

Abstract In the purification of monoclonal antibodies, ion‐exchange chromatography is typically used among the polishing steps to reduce...

SCIENTIST, ANTIBODY ANALYTICS - SORRENTO THERAPEUTICS - SAN DIEGO, CA

As a Scientist you will work closely with other groups across Sorrento to drive early discovery research programs into early clinical...

 
 
 

ITALIAN CANCER STARTUP PHILOGEN GETS OFF AN IMPRESSIVE $70M FUNDING ROUND

Quiet antibody biotech Philogen, which has had a difficult and long path, got off a healthy €62 million funding round and brought on...

EFFECT OF PROTEIN CRYOCONCENTRATION AND PROCESSING CONDITIONS ON KINETICS OF DIMER FORMATION FOR A MONOCLONAL ANTIBODY: A CASE STUDY ON BIOPROCESSING

Abstract Monoclonal antibodies may be prone to self‐association leading to formation of dimers, trimers or other high molecular weight...

 
 
 
Unique Synthetic Antibodies Show Promise for Improved Disease and Toxin Detection

UNIQUE SYNTHETIC ANTIBODIES SHOW PROMISE FOR IMPROVED DISEASE AND TOXIN DETECTION

Scientists have invented a new “synthetic antibody” that could make screening for diseases easier and less expensive than current go-to...

BRINGING CAR-T CANCER TREATMENTS TO SOLID TUMORS WITH HELP FROM ALPACAS

Scientists at Boston Children's Hospital and MIT built CAR-T cells that are inspired by alpaca antibodies and can target protective...

 
 
 
Safe and Effective Vaccine Developed Against Nipah Virus

SAFE AND EFFECTIVE VACCINE DEVELOPED AGAINST NIPAH VIRUS

A new safe and effective vaccine elicited a strong antibody response, protecting against Nipah virus which produces severe respiratory...

'NANOBODIES' FROM ALPACAS COULD HELP BRING CAR T-CELL THERAPY TO SOLID TUMORS

Most CAR T-cell therapies look for antigens specific to cancer cells. A new approach instead targets the environment around the tumor,...

 
 
 
Novel Technique to Detect Viral Infections Developed

NOVEL TECHNIQUE TO DETECT VIRAL INFECTIONS DEVELOPED

Newly developed technique can help identify viral infections effectively. Using a small wire, scientists have developed a sensor that...